The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2024
Filed:
Aug. 25, 2017
Applicant:
Nantomics, Llc, Culver City, CA (US);
Inventors:
Andrew Nguyen, San Jose, CA (US);
John Zachary Sanborn, Santa Cruz, CA (US);
Shahrooz Rabizadeh, Los Angeles, CA (US);
Assignee:
NantOmics, LLC, Culver City, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G16B 25/10 (2019.01); G16B 30/10 (2019.01); G16B 20/00 (2019.01); G16H 50/30 (2018.01); G16H 50/20 (2018.01); G16B 20/20 (2019.01); G16B 40/00 (2019.01); C12Q 1/6827 (2018.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
G16B 25/10 (2019.02); C12Q 1/6827 (2013.01); C12Q 1/6869 (2013.01); G16B 20/00 (2019.02); G16B 20/20 (2019.02); G16B 30/10 (2019.02); G16B 40/00 (2019.02); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G01N 2570/00 (2013.01); Y02A 90/10 (2018.01);
Abstract
Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.