The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2024
Filed:
Aug. 19, 2021
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Michael R. Green, Boylston, MA (US);
Minggang Fang, Northborough, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C12N 15/113 (2010.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); C07K 14/47 (2013.01); A61K 45/06 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01);
Abstract
Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).