The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2024
Filed:
May. 09, 2018
Applicant:
Generos Biopharma Ltd., Shanghai, CN;
Inventors:
Xin-Yuan Fu, Moreno Valley, CA (US);
Yi Zhou, Singapore, SG;
Assignee:
GenEros Biopharma Ltd., Shanghai, CN;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61P 25/28 (2006.01); A61K 31/7105 (2006.01); C12N 9/22 (2006.01); C07K 16/28 (2006.01); A61K 31/366 (2006.01); A61K 31/575 (2006.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); A61K 31/366 (2013.01); A61K 31/575 (2013.01); A61K 31/7105 (2013.01); A61P 25/28 (2018.01); C07K 16/248 (2013.01); C07K 16/249 (2013.01); C12N 9/22 (2013.01);
Abstract
Disclosed are methods for treating or preventing or delaying outset of Alzheimer's disease (AD) in a subject by targeting the novel pathway STAT1-CH25H in AD pathogenesis, specifically by administering to the subject a pharmaceutically effective amount of a STAT1 inhibitor, a CH25H inhibitor, or a 25-OHC inhibitor, for example, a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor such as simvastatin.