The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 16, 2024

Filed:

Jun. 02, 2017
Applicant:

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;

Inventors:

Hong Liu, Shanghai, CN;

Jia Li, Shanghai, CN;

Wei Zhu, Shanghai, CN;

Yubo Zhou, Shanghai, CN;

Jiang Wang, Shanghai, CN;

Mingbo Su, Shanghai, CN;

Shuni Wang, Shanghai, CN;

Wei Xu, Shanghai, CN;

Chunpu Li, Shanghai, CN;

Weijuan Kan, Shanghai, CN;

Hualiang Jiang, Shanghai, CN;

Kaixian Chen, Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 215/58 (2006.01); C07D 209/04 (2006.01); C07D 215/00 (2006.01); C07D 487/04 (2006.01); C07D 209/08 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61P 35/00 (2018.01); C07D 209/04 (2013.01); C07D 209/08 (2013.01); C07D 215/00 (2013.01); C07D 215/58 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 487/04 (2013.01); Y02P 20/55 (2015.11);
Abstract

The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to the chemical compound of formula (I), and its racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, and mixtures thereof, as well as its method for preparation, a pharmaceutical composition containing said chemical compound, and use as a lysine-specific demethylase 1 (LSD 1) inhibitor. The cyclopropylamine chemical compound to which the present invention relates may be used in the treatment of cancer.


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