The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 16, 2024

Filed:

Feb. 25, 2020
Applicant:

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Inventors:

Wenbin Lin, Chicago, IL (US);

Demin Liu, Round Lake, IL (US);

Joseph Della Rocca, Blue Bell, PA (US);

Stephanie Kramer, Johnson City, TN (US);

Christopher Y. Poon, Carlsbad, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); A61K 9/14 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61P 19/10 (2006.01); A61P 19/08 (2006.01); A61K 31/663 (2006.01); A61K 49/00 (2006.01); A61K 9/127 (2006.01); A61K 47/54 (2017.01); A61P 35/00 (2006.01); A61K 31/675 (2006.01); A61K 51/12 (2006.01);
U.S. Cl.
CPC ...
A61K 9/127 (2013.01); A61K 9/0019 (2013.01); A61K 9/14 (2013.01); A61K 9/5115 (2013.01); A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61K 31/663 (2013.01); A61K 31/675 (2013.01); A61K 47/548 (2017.08); A61K 47/6925 (2017.08); A61K 47/6929 (2017.08); A61K 49/00 (2013.01); A61K 51/1244 (2013.01); A61P 19/08 (2018.01); A61P 19/10 (2018.01); A61P 35/00 (2018.01);
Abstract

Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.


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