The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2024
Filed:
Jan. 22, 2021
Applicant:
University of Georgia Research Foundation, Inc., Athens, GA (US);
Inventor:
Geert-Jan Boons, Athens, GA (US);
Assignee:
University of Georgia Research Foundation, Inc., Athens, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 31/4188 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4188 (2013.01); A61K 47/6803 (2017.08); A61K 47/6809 (2017.08); A61K 47/6849 (2017.08); A61K 49/0043 (2013.01); A61K 49/0058 (2013.01); C07K 16/00 (2013.01); C07K 16/2803 (2013.01); C07K 2317/41 (2013.01); C07K 2317/92 (2013.01);
Abstract
Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.