The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Aug. 25, 2021
The Translational Genomics Research Institute, Phoenix, AZ (US);
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Sara Byron, Phoenix, AZ (US);
Jessica Aldrich, Phoenix, AZ (US);
John Carpten, Phoenix, AZ (US);
David Craig, Phoenix, AZ (US);
Mitesh Borad, Scottsdale, AZ (US);
Alan Bryce, Scottsdale, AZ (US);
Michael Barrett, Scottsdale, AZ (US);
George Vasmatzis, Rochester, MN (US);
Keith Stewart, Scottsdale, AZ (US);
The Translational Genomics Research Institute, Phoenix, AZ (US);
Abstract
Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.