The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Oct. 23, 2020
Applicant:
Danmarks Tekniske Universitet, Kongens Lyngby, DK;
Inventors:
Hao Luo, Kongens Lyngby, DK;
Jochen Förster, Kongens Lyngby, DK;
Assignee:
Danmarks Tekniske Universitet, Kongens Lyngby, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); C12N 9/78 (2006.01); C12N 9/02 (2006.01); C12P 17/10 (2006.01); C12P 13/22 (2006.01); C12P 7/22 (2006.01); C12N 1/16 (2006.01); C12N 1/14 (2006.01); C12N 1/20 (2006.01);
U.S. Cl.
CPC ...
C12N 9/78 (2013.01); C12N 1/14 (2013.01); C12N 1/16 (2013.01); C12N 1/20 (2013.01); C12N 9/0071 (2013.01); C12N 9/88 (2013.01); C12P 7/22 (2013.01); C12P 13/225 (2013.01); C12P 13/227 (2013.01); C12P 17/10 (2013.01); C12Y 114/16001 (2013.01); C12Y 114/16002 (2013.01); C12Y 114/16004 (2013.01); C12Y 305/04016 (2013.01); C12Y 402/01096 (2013.01);
Abstract
Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acids, vectors and methods useful for preparing and using such cells. In specific aspects, the present invention relates to monooxygenases, e.g., amino acid hydroxylases, with a modified cofactor-dependency, and to enzyme variants and microbial cells providing for an improved supply of cofactors.