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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11866742 B1

PDFFull Text
Date of Patent:
Jan. 09, 2024

Filed:

Nov. 23, 2020

Fusion proteins comprising enzyme replacement therapy enzymes

Applicant:

Denali Therapeutics Inc., South San Francisco, CA (US);

Inventors:

Anastasia Henry, South San Francisco, CA (US);

Mihalis S. Kariolis, San Mateo, CA (US);

Cathal S. Mahon, San Francisco, CA (US);

Adam P. Silverman, San Carlos, CA (US);

Ankita Srivastava, South San Francisco, CA (US);

Julie Ullman, San Francisco, CA (US);

Assignee:

DENALI THERAPEUTICS INC., South San Francisco, CA (US);

Attorney:

Viksnins Harris Padys Malen LLP

Primary Examiner:

Michael D Pak

Int. Cl.
CPC ...
A61K 38/43 (2006.01); C12N 9/16 (2006.01); C07K 14/00 (2006.01); A61K 47/68 (2017.01); C07K 19/00 (2006.01); C12N 15/62 (2006.01); C07K 16/28 (2006.01); C12N 9/18 (2006.01); C12N 9/24 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); A61K 47/68 (2017.08); C07K 14/00 (2013.01); C07K 16/28 (2013.01); C07K 16/2881 (2013.01); C07K 19/00 (2013.01); C12N 9/18 (2013.01); C12N 9/2402 (2013.01); C12N 15/62 (2013.01); C12Y 301/06013 (2013.01); A61K 38/00 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01); C12Y 301/04012 (2013.01); C12Y 302/01045 (2013.01); C12Y 310/01001 (2013.01);
Abstract

Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

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Henry, Anastasia. (2024). Fusion proteins comprising enzyme replacement therapy enzymes (U.S. Patent No. 11866742). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11866742

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