The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Dec. 29, 2020
Tianjin University of Science and Technology, Tianjin, CN;
Chenglin Zhang, Tianjin, CN;
Qingyang Xu, Tianjin, CN;
Yanjun Li, Tianjin, CN;
Yu Zhang, Tianjin, CN;
Yingzi Li, Tianjin, CN;
Fuzhou Zhu, Tianjin, CN;
Nan Lu, Tianjin, CN;
Shibao Han, Tianjin, CN;
Xierong Dong, Tianjin, CN;
Zishen Wang, Tianjin, CN;
Hao Xu, Tianjin, CN;
Ziyi Li, Tianjin, CN;
Tianjin University of Science and Technology, Tianjin, CN;
Abstract
The invention relates to a 2-isopropyl malate synthase, a genetically engineered bacterium for producing L-leucine and application thereof and belongs to the field of metabolic engineering. The genetically engineered bacterium is obtained by overexpressing an isopropyl malate synthase coding gene leuAfor relieving feedback inhibition by L-leucine, an acetohydroxy acid synthase coding gene ilvBNfor relieving feedback inhibition by L-isoleucine, a 3-isopropyl malate dehydrogenase coding gene leuB and a 3-isopropyl malate dehydratase coding gene leuCD in host cells. The genetically engineered bacterium for producing the L-leucine is free from nutritional deficiency, rapid in growth, short in fermentation period, high in yield and high in conversion rate.