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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11866736 B1

PDFFull Text
Date of Patent:
Jan. 09, 2024

Filed:

Aug. 01, 2016

Protein prostheses for mitochondrial diseases or conditions

Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Vamsi Mootha, Boston, MA (US);

Denis Titov, Boston, MA (US);

Valentin Cracan, Boston, MA (US);

Zenon Grabarek, Boston, MA (US);

Assignee:

The General Hospital Corporation, Boston, MA (US);

Attorney:

Clark & Elbing LLP

Primary Examiner:

Anne Marie S Wehbe

Int. Cl.
CPC ...
C12N 9/02 (2006.01); C12N 5/10 (2006.01); C07K 14/335 (2006.01); C07K 14/195 (2006.01); C12N 5/071 (2010.01); C12N 15/52 (2006.01); C12N 15/85 (2006.01); A61K 47/66 (2017.01); A61P 25/16 (2006.01); A61K 9/127 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61K 47/18 (2017.01); A61K 47/42 (2017.01); C12N 15/113 (2010.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0036 (2013.01); C07K 14/195 (2013.01); C07K 14/335 (2013.01); C12N 5/0602 (2013.01); C12N 5/10 (2013.01); C12N 15/52 (2013.01); C12N 15/85 (2013.01); C12Y 106/03001 (2013.01); A61K 9/127 (2013.01); A61K 38/162 (2013.01); A61K 38/1709 (2013.01); A61K 38/1774 (2013.01); A61K 47/18 (2013.01); A61K 47/42 (2013.01); A61K 47/66 (2017.08); A61P 25/16 (2018.01); C07K 2319/07 (2013.01); C07K 2319/43 (2013.01); C12N 15/113 (2013.01); C12N 15/62 (2013.01);
Abstract

The invention encompasses water-forming NADH and NADPH oxidases and the use of these enzymes to treat mammalian diseases or conditions associated with an elevated NADH/NAD+ ratio or NADPH/NADP+ ratio. Such pathologies include disorders caused by one or more defects in the mitochondrial respiratory chain, glucose metabolism disorders, cancers associated with reductive stress, and aging. The invention also provides a research tool for investigating the effect of exogenous water-forming NADH or NADPH oxidases on the metabolism of a mammalian cell, such as a human cell, and for elucidating the role of respiratory chain proteins in mitochondrial disorders.

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