The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 09, 2024

Filed:

May. 18, 2018
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Feng Zhang, Cambridge, MA (US);

David Benjamin Turitz Cox, Cambridge, MA (US);

Jonathan Gootenberg, Cambridge, MA (US);

Omar O. Abudayyeh, Cambridge, MA (US);

Bernd Zetsche, Cambridge, MA (US);

Jonathan Strecker, Cambridge, MA (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/10 (2006.01); C12N 9/22 (2006.01); C12N 15/62 (2006.01); C12N 15/10 (2006.01); A61K 48/00 (2006.01); C12N 15/11 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
C12N 15/102 (2013.01); A61K 48/00 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/62 (2013.01); C12N 15/79 (2013.01); C12N 2310/533 (2013.01); C12Y 305/04004 (2013.01);
Abstract

The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a DNA-targeting Cpf1 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.


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