The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Dec. 18, 2018
Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof
Blaze Bioscience, Inc., Seattle, WA (US);
Natalie Winblade Nairn, Seattle, WA (US);
Julia Novak, Sequim, WA (US);
Kenneth Grabstein, Mercer Island, WA (US);
Dennis Miller, Woodinville, WA (US);
Greg T. Hermanson, Loves Park, IL (US);
Scott R. Presnell, Tacoma, WA (US);
Mark Stroud, Seattle, WA (US);
BLAZE BIOSCIENCE, INC., Seattle, WA (US);
Abstract
Peptide-immuno-oncology agent complexes ('peptide-I/O complexes') that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.