The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 09, 2024

Filed:

May. 29, 2020
Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Jin-quan Yu, San Diego, CA (US);

Zhe Zhuang, San Diego, CA (US);

Assignee:

The Scripps Research Institute, La Jolla, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 305/12 (2006.01); C07D 405/06 (2006.01); C07D 407/04 (2006.01); C07D 407/06 (2006.01); C07F 9/655 (2006.01);
U.S. Cl.
CPC ...
C07D 305/12 (2013.01); C07D 405/06 (2013.01); C07D 407/04 (2013.01); C07D 407/06 (2013.01); C07F 9/6551 (2013.01);
Abstract

Provided herein is a method of forming a beta-lactone from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon. The method comprises contacting a carboxylic acid of formula (1) as described herein with an effective amount of a palladium(II) catalyst, an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C. to provide a beta-lactone of formula (2) as described herein.


Find Patent Forward Citations

Yu, Jin-quan. (2024). Ligand-enabled β-c(sp)-h lactonization for β-c—h functionalizations (U.S. Patent No. 11866415). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11866415

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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