The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Nov. 02, 2016
Applicant:
Carmel-haifa University Economic Corporation Ltd., Haifa, IL;
Inventors:
Sarit Larisch, Zichron Yaakov, IL;
Dalit Barkan, Zichron Yaakov, IL;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/42 (2006.01); C07D 231/14 (2006.01); C07D 217/02 (2006.01); A61K 31/496 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 209/42 (2013.01); A61K 31/496 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 217/02 (2013.01); C07D 231/14 (2013.01);
Abstract
Provided are ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Further, the novel ARTS mimetic compounds of the presently claimed subject matter induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. Further provided are compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.