The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Apr. 27, 2022
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Girija Goyal, Cambridge, MA (US);
Donald E. Ingber, Boston, MA (US);
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); C12N 5/0781 (2010.01); C12N 5/0783 (2010.01); A61K 35/28 (2015.01); A61P 35/00 (2006.01); A61K 35/17 (2015.01); C12M 3/06 (2006.01); A61P 37/04 (2006.01); C12M 3/00 (2006.01); A61P 7/00 (2006.01); C12N 5/00 (2006.01); C12N 5/0786 (2010.01); C12N 5/078 (2010.01); C12N 5/071 (2010.01); C12N 5/09 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
B01L 3/5027 (2013.01); A61K 35/17 (2013.01); A61K 35/28 (2013.01); A61P 7/00 (2018.01); A61P 35/00 (2018.01); A61P 37/04 (2018.01); C12M 21/08 (2013.01); C12M 23/16 (2013.01); C12N 5/0018 (2013.01); C12N 5/069 (2013.01); C12N 5/0635 (2013.01); C12N 5/0636 (2013.01); C12N 5/0645 (2013.01); C12N 5/0651 (2013.01); C12N 5/0693 (2013.01); G01N 33/5011 (2013.01); B01L 2300/0861 (2013.01); C12N 2531/00 (2013.01); C12N 2533/52 (2013.01); C12N 2533/54 (2013.01); C12N 2533/90 (2013.01);
Abstract
An organ-on-a-chip microfluidic device is disclosed that mimics a human lymph node and/or human lymphoid tissue. The device can include cells from human blood and lymphatic tissue, include an extracellular matrix for the development of immune system components, and provide for the perfusion of fluids and solids resembling blood and lymphatic fluid within micrometer sized channels.