The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Dec. 30, 2020
Massachusetts Institute of Technology, Cambridge, MA (US);
The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Bethesda, MD (US);
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Alexander K. Shalek, Cambridge, MA (US);
Travis Hughes, Cambridge, MA (US);
Marc H. Wadsworth, Cambridge, MA (US);
Robert Seder, Bethesda, MD (US);
Mario Roederer, Bethesda, MD (US);
Joanne L. Flynn, Pittsburgh, PA (US);
Patricia Darrah, Bethesda, MD (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The United States of America, as represented by The Secretary, Department of Health & Human Services, Bethesda, MD (US);
University of Pittsburgh—Of The Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Provided herein are compositions and methods for therapeutic and/or prophylactic treatment of an intracellular bacterial infection in a subject in need thereof, comprising one or more modulating agents, wherein the one or more modulating agents increase expression of IFNγ, IL-2, TNF, and/or IL-17 in systemic and/or lung T cells. In some embodiments, the increase of expression of IFNγ, IL-2, TNF, and/or IL-17 occurs in lung T cells. The lung T cells can be lung resident T cells or systemic T cells that are recruited to the lung. In some embodiments, the T cells are CD4+ and/or CD8+ T cells. In some embodiments, the intracellular bacterial infection is a(MTB) infection.