The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Nov. 29, 2018
The Cleveland Clinic Foundation, Cleveland, OH (US);
Jaroslaw Maciejewski, Cleveland, OH (US);
Babal K. Jha, Cleveland, OH (US);
James G. Phillips, Cleveland, OH (US);
Thomas Radivoyevitch, Cleveland, OH (US);
Yihong Guan, Cleveland, OH (US);
Anand D. Tiwari, Cleveland, OH (US);
THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);
Abstract
A method of treating cancer is described. The method includes administering a therapeutically effective amount of a TET2 activating compound or pharmaceutically acceptable salt thereof to a subject in need of treatment. The TET2 activating compounds are α-ketoglutarate derivatives. A method of treating or preventing cancer in a subject that includes the step of analyzing a biological sample to determine if cells of the biological sample exhibit a TET2 mutation in addition to administering a TET2 activator is also described.