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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11860154 B1

PDFFull Text
Date of Patent:
Jan. 02, 2024

Filed:

May. 27, 2021

Method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos

Applicant:

Leuko Labs, Inc., Boston, MA (US);

Inventors:

Carlos Castro Gonzalez, Cambridge, MA (US);

Ian Butterworth, Somerville, MA (US);

Aurelien Bourquard, Madrid, ES;

Alvaro Sanchez Ferro, Madrid, ES;

Assignee:

Leuko Labs, Inc, Boston, MA (US);

Attorney:

Iandiorio Teska & Coleman, LLP

Primary Examiner:

Emily C Terrell

Assistant Examiner:

Nathan J Bloom

Int. Cl.
CPC ...
G01N 33/49 (2006.01); G06T 7/00 (2017.01); G06T 7/11 (2017.01); G06T 7/38 (2017.01); G16H 30/20 (2018.01); G16H 30/40 (2018.01); G16H 50/20 (2018.01); G16H 50/70 (2018.01); G01N 21/31 (2006.01); G06V 20/69 (2022.01); G06F 18/214 (2023.01); G06V 10/764 (2022.01); G06V 10/82 (2022.01); G06V 10/56 (2022.01); G01N 15/14 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 33/49 (2013.01); G01N 15/147 (2013.01); G01N 15/1429 (2013.01); G01N 15/1475 (2013.01); G01N 21/31 (2013.01); G06F 18/2148 (2023.01); G06T 7/0016 (2013.01); G06T 7/11 (2017.01); G06T 7/38 (2017.01); G06V 10/56 (2022.01); G06V 10/764 (2022.01); G06V 10/82 (2022.01); G06V 20/695 (2022.01); G06V 20/698 (2022.01); G16H 30/20 (2018.01); G16H 30/40 (2018.01); G16H 50/20 (2018.01); G16H 50/70 (2018.01); G01N 2015/008 (2013.01); G01N 2015/0073 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1443 (2013.01); G01N 2015/1486 (2013.01); G06T 2207/10016 (2013.01); G06T 2207/10056 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/20084 (2013.01); G06T 2207/30101 (2013.01); G06T 2207/30242 (2013.01); G06V 2201/03 (2022.01);
Abstract

In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images. The method also includes acquiring a second plurality of images of the same region of interest of the same capillary with an advanced optical device capable of resolving cellular structure of white blood cells and white blood cell subtypes and spatiotemporally annotating the second plurality of images with an indication of any white blood cell detected and/or a subtype of any white blood cell detected in the second plurality of images. The method also includes inputting the first plurality of images and annotated information from the first plurality of images and annotated information from the spatiotemporally annotated second plurality of images into a machine learning subsystem configured to determine a presence of white blood cells and/or the subtype of any white blood cells present in the one or more optical absorption gaps in the first plurality of images.

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