The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2024

Filed:

Nov. 08, 2019
Applicant:

Academia Sinica, Taipei, TW;

Inventors:

Chia-Fu Chou, Taipei, TW;

Jia-Wei Yeh, Taipei, TW;

Yii-Lih Lin, Taipei, TW;

Assignee:

ACADEMIA SINICA, Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); B01L 3/00 (2006.01); G01N 15/14 (2006.01); G01N 33/487 (2006.01); G01N 15/10 (2006.01); G01N 27/327 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/68 (2013.01); B01L 3/50273 (2013.01); G01N 15/1404 (2013.01); G01N 33/487 (2013.01); B01L 2300/041 (2013.01); B01L 2300/047 (2013.01); B01L 2300/06 (2013.01); B01L 2400/0406 (2013.01); G01N 27/3272 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1493 (2013.01);
Abstract

A method for sizing a DNA molecule is disclosed, which comprises the following steps of: providing a DNA sizing device, comprising: a cover substrate; a substrate disposed on the cover substrate and comprising a first hole and a second hole; and a first slit-like channel disposed between the cover substrate and the substrate, wherein two ends of the first slit-like channel respectively connects to the first hole and the second hole; loading a sample comprising a DNA molecule to the first slit-like channel through the first hole, wherein the DNA molecule moves in a direction from the first hole to the second hole; detecting and recording an intensity and an area of a distribution of the DNA molecule; and analyzing the intensity and the area to obtain the size of a DNA molecule.


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