The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2024

Filed:

Aug. 11, 2022
Applicants:

Synlogic Operating Company, Inc., Cambridge, MA (US);

Ginkgo Bioworks, Inc., Boston, MA (US);

Inventors:

Dylan Alexander Carlin, Jamaica Plain, MA (US);

Vincent M. Isabella, Medford, MA (US);

Jonathan McMurry, Boston, MA (US);

Theodore Carlton Moore, III, Cambridge, MA (US);

Mylene Perreault, Lexington, MA (US);

Nathan Schmidt, Milton, MA (US);

Mark Simon, Gainesville, FL (US);

Assignees:

Synlogic Operating Company, Inc., Cambridge, MA (US);

Ginkgo Bioworks, Inc., Boston, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); C12N 15/52 (2006.01); A61K 35/741 (2015.01); C12N 15/70 (2006.01); C07K 14/245 (2006.01);
U.S. Cl.
CPC ...
C12N 15/52 (2013.01); A61K 35/741 (2013.01); C07K 14/245 (2013.01); C12N 9/88 (2013.01); C12N 15/70 (2013.01); C12Y 401/01057 (2013.01); C12Y 404/01011 (2013.01);
Abstract

The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.


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