The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Dec. 21, 2018
Industrial Technology Research Institute, Hsinchu, TW;
National Taiwan University Hospital, Taipei, TW;
Cheng-Tai Chen, Taoyuan, TW;
Chien-An Chen, New Taipei, TW;
Wen-Ting Chiang, Hsinchu County, TW;
Su-Feng Chiu, Miaoli County, TW;
Pei-Shin Jiang, Hsinchu, TW;
Jih-Luh Tang, Taipei, TW;
Chien-Ting Lin, Taipei, TW;
Xuan-Hui Lin, New Taipei, TW;
Industrial Technology Research Institute, Hsinchu, TW;
National Taiwan University Hospital, Taipei, TW;
Abstract
A method for in vitro activation and/or expansion of immune cells is provided, including the steps of: a) providing magnetic particles having multi-protrusive surface modified with at least one type of immuno-inducing substance, in which each magnetic particle includes a copolymer core, a polymer layer, a magnetic substance layer, and a silicon-based layer from the inside to the outside; b) providing a cell solution including at least one type of immune cell in the cell solution; and c) bringing the magnetic particles in contact with the cell solution, in which the at least one type of immuno-inducing substance on the surface of the magnetic particle activates and/or expands the at least one type of immune cell in the cell solution.