The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Dec. 29, 2020
Applicant:
Ohio State Innovation Foundation, Columbus, OH (US);
Inventor:
Dehua Pei, Columbus, OH (US);
Assignee:
Ohio State Innovation Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/56 (2006.01); A61P 29/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/56 (2013.01); A61P 29/00 (2018.01); A61K 38/00 (2013.01);
Abstract
Anticachexin C1 inhibits the TNFα-TNFα receptor interaction. In this work, analogs of anticachexin C1 are disclosed. The resulting bicyclic peptides inhibit TNFα TNFα-induced cell death, NF-κB activation, and c-Jun N-terminal kinase (JNK) signaling in cultured mammalian cells. Methods of using the bicyclic peptide anticachexin C1 analogs to treat cancer, inflammatory disorders and immune disorders are also described.