The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Sep. 22, 2022
Immatics Biotechnologies Gmbh, Tuebingen, DE;
Gabriele Pszolla, Tuebingen, DE;
Martin Hofmann, Tuebingen, DE;
Meike Hutt, Tuebingen, DE;
Sebastian Bunk, Tuebingen, DE;
Felix Unverdorben, Tuebingen, DE;
Frank Schwoebel, Tuebingen, DE;
Dominik Maurer, Tuebingen, DE;
Maike Jaworski, Tuebingen, DE;
Claudia Wagner, Tuebingen, DE;
Florian Schwoerer, Tuebingen, DE;
Heiko Schuster, Tuebingen, DE;
IMMATICS BIOTECHNOLOGIES GMBH, Tuebingen, DE;
Abstract
The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.