The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2024

Filed:

Aug. 09, 2017
Applicant:

Kymab Limited, Cambridge, GB;

Inventors:

Richard Charles Alfred Sainson, Cambridge, GB;

Stephen John Arkinstall, Cambridge, GB;

Jamie Iain Campbell, Cambridge, GB;

Mohammed Hanif Ali, Cambridge, GB;

E-Chiang Lee, Cambridge, GB;

Matthew John McCourt, Cambridge, GB;

Volker Germaschewski, Cambridge, GB;

Ian Kirby, Cambridge, GB;

Miha Kosmac, Cambridge, GB;

Nahida Parveen, Cambridge, GB;

Robert Rowlands, Cambridge, GB;

Gwenoline Borhis, Cambridge, GB;

Assignee:

KYMAB LIMITED, Cambridge, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/02 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61K 31/282 (2006.01); C07K 14/55 (2006.01); C07K 16/46 (2006.01); G01N 33/50 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2818 (2013.01); A61K 31/282 (2013.01); A61K 39/395 (2013.01); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); C07K 14/55 (2013.01); C07K 16/2827 (2013.01); C07K 16/468 (2013.01); G01N 33/5026 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); A61K 2039/545 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/40 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.


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