The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Jun. 26, 2020
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Tatsumi Yamazaki, Tokyo, JP;
Hisafumi Okabe, Shizuoka, JP;
Shinta Kobayashi, Helios, SG;
Takeshi Watanabe, Shizuoka, JP;
Koichi Matsubara, Helios, SG;
Osamu Natori, Helios, SG;
Atsuhiko Kato, Shizuoka, JP;
Masami Suzuki, Shizuoka, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker Lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients. The present inventors discovered that highly pure large intestine cancer stem cells (CSC) can be obtained in a large quantity, and identified the two types of conditions of large intestine CSCs distinguishable through Lgr5 expression. Moreover, the present inventors discovered that an antibody against a cell membrane molecule specifically expressed in said cancer stem cells can damage said cells.