The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Sep. 17, 2019
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Viviana Gradinaru, La Canada Flintridge, CA (US);
Claire N. Bedbrook, Pasadena, CA (US);
Frances H. Arnold, La Canada Flintridge, CA (US);
Kevin K. Yang, Cambridge, MA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/16 (2006.01); C07K 14/405 (2006.01); A61P 27/02 (2006.01); C12N 15/86 (2006.01); A61N 5/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/405 (2013.01); A61N 5/062 (2013.01); A61N 5/0622 (2013.01); A61P 27/02 (2018.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61N 2005/063 (2013.01); A61N 2005/0647 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Disclosed herein are engineered light-sensitive proteins, for example channelrhodopsins and variants thereof. Also disclosed are compositions for expressing the light-sensitive proteins in cells, tissues, organs and subjects, and methods for using the light-sensitive proteins to, for example, enable minimally-invasive neuronal circuit interrogation in living organism, and treat neuronal and ocular disorders.