The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Feb. 06, 2020
Applicant:
Ardelyx, Inc., Fremont, CA (US);
Inventors:
Dean Dragoli, Fremont, CA (US);
Gary Luehr, Fremont, CA (US);
Tao Chen, Fremont, CA (US);
Jason Lewis, Fremont, CA (US);
Michael Leadbetter, Fremont, CA (US);
Assignee:
Ardelyx, Inc., Fremont, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 63/00 (2006.01); A61P 3/12 (2006.01); A61K 31/56 (2006.01); A61P 5/40 (2006.01); A61K 31/58 (2006.01);
U.S. Cl.
CPC ...
C07J 63/008 (2013.01); A61K 31/56 (2013.01); A61K 31/58 (2013.01); A61P 3/12 (2018.01); A61P 5/40 (2018.01);
Abstract
The present invention provides a compound of formula (I) or a salt thereof: (Formula (I)) wherein X, L, V, R; R, Rand R, are as defined herein. The claimed compounds inhibit the enzyme 11-hydroxysteroid dehydrogenase type 2 (11-HSD2) and as a result are useful in the treatment of hyperkalemia by preventing cortisol from being oxidised to cortisone and thus allowing it to occupy the mineralocorticoid receptor, thus stimulating potassium excretion.