The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2024

Filed:

Dec. 28, 2020
Applicant:

Alkermes, Inc., Waltham, MA (US);

Inventors:

Martin R. Jefson, Stonington, CT (US);

John A. Lowe, III, Stonington, CT (US);

Fabian Dey, Basel, CH;

Andreas Bergmann, Gauting, DE;

Andreas Schoop, Grafrath, DE;

Nathan Oliver Fuller, Arlington, MA (US);

Assignee:

Alkermes, Inc., Waltham, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/13 (2006.01); A61K 31/167 (2006.01); A61K 31/27 (2006.01); A61K 31/435 (2006.01); A61K 31/44 (2006.01); A61K 31/444 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 309/14 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 207/06 (2006.01); C07D 513/04 (2006.01); C07D 417/12 (2006.01); C07D 413/14 (2006.01); A61K 31/437 (2006.01); A61K 31/4985 (2006.01); A61K 31/351 (2006.01); A61K 31/4433 (2006.01); C07D 409/12 (2006.01); A61K 31/506 (2006.01); C07D 491/107 (2006.01); C07D 487/10 (2006.01); A61K 31/4439 (2006.01); C07D 417/14 (2006.01); A61K 31/4155 (2006.01); A61K 31/55 (2006.01); A61K 31/496 (2006.01); A61K 31/427 (2006.01); A61K 31/4965 (2006.01); A61K 31/445 (2006.01); A61K 31/50 (2006.01); A61K 31/4192 (2006.01); A61K 31/415 (2006.01); A61K 31/5377 (2006.01); A61K 31/40 (2006.01); A61K 31/426 (2006.01); A61K 45/06 (2006.01); A61K 31/505 (2006.01); A61K 31/421 (2006.01); C07D 471/10 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/13 (2013.01); A61K 31/167 (2013.01); A61K 31/27 (2013.01); A61K 31/351 (2013.01); A61K 31/40 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/4192 (2013.01); A61K 31/421 (2013.01); A61K 31/426 (2013.01); A61K 31/427 (2013.01); A61K 31/435 (2013.01); A61K 31/437 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/445 (2013.01); A61K 31/4433 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/4965 (2013.01); A61K 31/4985 (2013.01); A61K 31/50 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 207/06 (2013.01); C07D 309/14 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 513/04 (2013.01);
Abstract

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.


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