The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2024

Filed:

Dec. 30, 2021
Applicant:

The Board of Regents of the University of Texas System, Austin, TX (US);

Inventors:

Daniel J. Siegwart, Dallas, TX (US);

Kejin Zhou, Dallas, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 321/14 (2006.01); A61K 9/51 (2006.01); A61K 31/7105 (2006.01); A61K 31/7125 (2006.01); A61K 47/59 (2017.01); A61K 47/60 (2017.01); A61K 47/69 (2017.01); A61K 48/00 (2006.01); C07C 323/52 (2006.01); C07D 295/15 (2006.01); A61K 47/20 (2006.01); A61K 47/22 (2006.01);
U.S. Cl.
CPC ...
C07C 321/14 (2013.01); A61K 9/513 (2013.01); A61K 9/5146 (2013.01); A61K 31/7105 (2013.01); A61K 31/7125 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61K 47/59 (2017.08); A61K 47/60 (2017.08); A61K 47/6931 (2017.08); A61K 48/0041 (2013.01); C07C 323/52 (2013.01); C07D 295/15 (2013.01);
Abstract

Disclosed herein are methods for modulating an amount or activity of a gene or a gene product in a cell. The methods herein may comprise contacting a cell with a therapeutic agent assembled with a lipid composition, which lipid composition may comprise a dendrimer or dendron which may comprise one or more degradable diacyl group, in which may result in modulating the amount or activity of the gene or the gene product in the cell. The therapeutic agent modulating a gene or gene product in a cell may be sufficient to treat a disease or disorder in a subject. Further disclosed herein are pharmaceutical compositions, kits, and lipid compositions for modulating an amount or activity of a gene or a gene product in a cell.


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