The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2024

Filed:

Sep. 13, 2021
Applicant:

University of South Florida, Tampa, FL (US);

Inventors:

Edward Turos, Wesley Chapel, FL (US);

Faeez Mahzamani, Brandon, FL (US);

Assignee:

UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/14 (2006.01); A61K 9/107 (2006.01); A61P 31/04 (2006.01); A61K 47/58 (2017.01); A61K 31/496 (2006.01); A61K 47/20 (2006.01); A61K 47/55 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 9/1075 (2013.01); A61K 31/496 (2013.01); A61K 47/20 (2013.01); A61K 47/552 (2017.08); A61K 47/58 (2017.08); A61K 47/6907 (2017.08); A61P 31/04 (2018.01);
Abstract

The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such asand. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.


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