The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2024

Filed:

Nov. 02, 2018
Applicant:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

Dexing Zeng, Portland, OR (US);

Lingyi Sun, Pittsburgh, PA (US);

Yongkang Gai, Pittsburgh, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/08 (2006.01); C07K 16/30 (2006.01); C07K 7/06 (2006.01); C07K 7/64 (2006.01); G01N 33/50 (2006.01); G01N 33/60 (2006.01); A61K 51/10 (2006.01); A61K 47/68 (2017.01); C07D 255/02 (2006.01); C07D 257/02 (2006.01); A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
A61K 51/082 (2013.01); A61K 9/51 (2013.01); A61K 47/6893 (2017.08); A61K 51/1027 (2013.01); C07D 255/02 (2013.01); C07D 257/02 (2013.01); C07K 7/06 (2013.01); C07K 7/64 (2013.01); C07K 16/30 (2013.01); G01N 33/5008 (2013.01); G01N 33/60 (2013.01); C07K 2319/00 (2013.01);
Abstract

The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.


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