The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Mar. 30, 2021
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Andreas Herrmann, Del Mar, CA (US);
Hua Yu, Glendora, CA (US);
Assignee:
City of Hope, Duarte, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); A61K 47/54 (2017.01); C12N 15/113 (2010.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/549 (2017.08); A61K 47/548 (2017.08); A61K 48/00 (2013.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01);
Abstract
Provided herein are, inter alia, nucleic acid conjugates including a non-cell penetrating ribonucleic acid compound attached at its 3′ end to a phosphorothioate polymer. Attachment of the phosphorothioate polymer to the non-cell penetrating ribonucleic acid conveys stability to and allows for efficient intracellular delivery of the non-cell penetrating ribonucleic acid. The nucleic acid conjugates provided herein including embodiments thereof are useful, inter alia, for the treatment of cancer, inflammatory disease, and pain.