The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Jun. 17, 2021
Applicant:
Pfizer Inc., New York, NY (US);
Inventors:
Yuhang Liu, South Glastonbury, CT (US);
Ye Che, Niantic, CT (US);
Xiaoyuan Sherry Chi, Tenafly, NJ (US);
Philip Ralph Dormitzer, Nyack, NY (US);
Jennifer Anne Nicki, Gales Ferry, CT (US);
Xiaojie Yao, East Lyme, CT (US);
Assignee:
Pfizer Inc., New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/245 (2006.01); C07K 14/045 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/245 (2013.01); C07K 14/045 (2013.01); C12N 7/00 (2013.01); C12N 2710/16134 (2013.01);
Abstract
The present invention comprises mutants of a wild-type cytomegalovirus (CMV) glycoprotein B (gB) protein that include at least two introduced amino acid mutations relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB), compositions including the mutants and uses thereof. In some embodiments, the mutant is stabilized in a conformation alternative to the gB postfusion conformation.