The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Mar. 10, 2021
Immunitybio, Inc., Culver City, CA (US);
Patrick Soon-Shiong, Culver City, CA (US);
Peter Sieling, Culver City, CA (US);
Kayvan Niazi, Culver City, CA (US);
Shahrooz Rabizadeh, Culver City, CA (US);
Lise Geissert, Culver City, CA (US);
Annie Shin, Culver City, CA (US);
Adrian Rice, Culver City, CA (US);
Elizabeth Gabitzsch, Culver City, CA (US);
Jeffrey Safrit, Culver City, CA (US);
Leonard Sender, Culver City, CA (US);
ImmunityBio, Inc., Culver City, CA (US);
Abstract
Disclosed herein are methods for inducing immunity against a virus such as a coronavirus in the mucosal tissue of a patient, include administering a vaccine composition to the patient by oral administration (e.g., nasal injection, nasal inhalation, oral inhalation, and/or oral ingestion). Also disclosed are compositions for assaying the presence of antiviral antibodies induced by the administered vaccine or the presence of viral proteins in a saliva sample include a stabilizing solution and may also include the use of aragonite particle beads. Compositions and methods are presented for prevention and/or treatment of a coronavirus disease wherein the composition comprises comprises a recombinant entity. The recombinant entity is bivalent, comprising a nucleic acid encoding a coronavirus 2 nucleocapsid protein CoV2 nucleocapsid protein fused to an endosomal targeting sequence, and a nucleic acid encoding a CoV2 spike protein sequence optimized for cell surface expression.