The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2023
Filed:
Sep. 12, 2019
Applicant:
Editas Medicine, Inc., Cambridge, MA (US);
Inventors:
Jennifer Leah Gori, Jamaica Plain, MA (US);
Luis A. Barrera, Somerville, MA (US);
Edouard Aupepin De Lamothe-Dreuzy, Boston, MA (US);
Jack Heath, Boston, MA (US);
Assignee:
EDITAS MEDICINE, INC., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); A61K 31/7105 (2006.01); A61K 38/46 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 31/7105 (2013.01); A61K 38/465 (2013.01); C12N 15/111 (2013.01); C12N 2310/20 (2017.05); C12N 2320/30 (2013.01);
Abstract
Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.