The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2023
Filed:
Mar. 09, 2020
The United States of America, As Represented BY the Secretary, Department of Health, Bethesda, MD (US);
Biomed Valley Discoveries, Inc., Kansas City, MO (US);
Dimiter S. Dimitrov, Frederick, MD (US);
Zhongyu Zhu, Frederick, MD (US);
Bradley St. Croix, Frederick, MD (US);
Steven Seaman, Martinsburg, WV (US);
Saurabh Saha, Wellesley Hills, MA (US);
Xiaoyan Michelle Zhang, Lexington, MA (US);
Gary A. DeCrescenzo, Parkville, MO (US);
Dean Welsch, Parkville, MO (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
BioMed Valley Discoveries, Inc., Kansas City, MO (US);
Abstract
Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.