The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2023
Filed:
Nov. 04, 2015
Applicant:
Xlifesc, Ltd., Guangdong, CN;
Assignee:
XLIFESC, LTD., Guangdong, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); A61K 38/17 (2006.01); C12N 15/63 (2006.01); A61K 47/62 (2017.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 38/17 (2013.01); A61K 47/62 (2017.08); C07K 16/2809 (2013.01); C12N 15/63 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
Provided is a high-stability T cell receptor (TCR). The TCR comprises (i) the whole or a part of TCRα chain except a transmembrane domain thereof, and (ii) the whole or a part of TCRβ chain except a transmembrane domain thereof, both the (i) and the (ii) comprising a functional variable domain and at least a part of a constant domain of a TCR chain. An artificial interchain disulfide bond links the constant domains of the TCRα and β chains, and a Tm value of the T cell receptor is greater than or equal to 45° C.