The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 26, 2023

Filed:

Jan. 26, 2022
Applicant:

Kallyope, Inc., New York, NY (US);

Inventors:

Iyassu Sebhat, Jersey City, NJ (US);

Shuwen He, Fanwood, NJ (US);

Ann Weber, Cranford, NJ (US);

Nancy Thornberry, Westfield, NJ (US);

Lisa Krug, New York, NY (US);

Paul Richards, New York, NY (US);

Brett Lauring, New York, NY (US);

Assignee:

KALLYOPE, INC., New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 1/04 (2006.01); A61P 1/12 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 1/04 (2018.01); A61P 1/12 (2018.01);
Abstract

This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists or partial agonists.


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