The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2023
Filed:
Nov. 07, 2017
Applicant:
Ramot AT Tel-aviv University Ltd., Tel Aviv, IL;
Inventors:
Dan Peer, Kiryat Ono, IL;
Srinivas Ramishetti, Tel Aviv, IL;
Assignee:
RAMOT AT TEL-AVIV UNIVERSITY LTD., Tel Aviv, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 211/22 (2006.01); A61K 47/18 (2017.01); C07C 215/08 (2006.01); C07C 229/12 (2006.01); C07C 243/00 (2006.01); C07C 243/16 (2006.01); C07C 243/28 (2006.01); C07D 295/15 (2006.01); C12N 15/113 (2010.01); A61K 48/00 (2006.01); C07C 243/04 (2006.01); C07C 59/01 (2006.01); C07C 333/10 (2006.01); C07C 219/04 (2006.01); C07D 233/64 (2006.01); C07C 229/02 (2006.01); A61P 29/00 (2006.01); C07D 295/13 (2006.01); C07C 243/26 (2006.01); C07C 233/00 (2006.01); C07C 243/14 (2006.01); C07C 279/04 (2006.01); A61P 35/00 (2006.01); C07C 229/10 (2006.01); C07C 243/10 (2006.01);
U.S. Cl.
CPC ...
C07C 211/22 (2013.01); A61K 47/18 (2013.01); A61K 48/00 (2013.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C07C 59/01 (2013.01); C07C 215/08 (2013.01); C07C 219/04 (2013.01); C07C 229/02 (2013.01); C07C 229/10 (2013.01); C07C 229/12 (2013.01); C07C 233/00 (2013.01); C07C 243/00 (2013.01); C07C 243/10 (2013.01); C07C 243/14 (2013.01); C07C 243/16 (2013.01); C07C 243/26 (2013.01); C07C 243/28 (2013.01); C07C 279/04 (2013.01); C07C 333/10 (2013.01); C07D 233/64 (2013.01); C07D 295/13 (2013.01); C07D 295/15 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01);
Abstract
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.