logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11850285 B1

PDFFull Text
Date of Patent:
Dec. 26, 2023

Filed:

Mar. 07, 2018

Insulin-responsive glucagon delivery patch

Applicant:

North Carolina State University, Raleigh, NC (US);

Inventors:

Zhen Gu, Apex, NC (US);

Jicheng Yu, Raleigh, NC (US);

Assignee:

North Carolina State University, Raleigh, NC (US);

Attorney:

Jenkins, Taylor & Hunt, P.A.

Primary Examiner:

David Browe

Int. Cl.
CPC ...
A61K 47/64 (2017.01); A61K 47/61 (2017.01); A61K 47/69 (2017.01); A61K 47/56 (2017.01); A61P 3/10 (2006.01); A61K 9/00 (2006.01); A61K 38/26 (2006.01); A61K 38/28 (2006.01); A61K 47/32 (2006.01); A61M 37/00 (2006.01); B29C 39/02 (2006.01); B29C 39/12 (2006.01); C12N 15/115 (2010.01); B29K 105/00 (2006.01); B29L 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/645 (2017.08); A61K 9/0021 (2013.01); A61K 38/26 (2013.01); A61K 38/28 (2013.01); A61K 47/32 (2013.01); A61K 47/56 (2017.08); A61K 47/61 (2017.08); A61K 47/6903 (2017.08); A61M 37/0015 (2013.01); A61P 3/10 (2018.01); B29C 39/026 (2013.01); B29C 39/123 (2013.01); C12N 15/115 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); A61M 2037/0061 (2013.01); B29K 2105/0035 (2013.01); B29K 2995/006 (2013.01); B29K 2995/0092 (2013.01); B29L 2031/756 (2013.01); B29L 2031/7544 (2013.01); C12N 2310/16 (2013.01);
Abstract

A composition comprising an insulin-polymer conjugate and an insulin aptamer-glucagon conjugate is described. Depending upon the amount of insulin in the environment surrounding the composition, the insulin aptamer of the insulin aptamer-glucagon conjugate can bind to insulin in the insulin-polymer conjugate to form a non-covalent conjugate. When the amount of insulin in the surrounding environment rises, the insulin aptamer-glucagon conjugate can be released. Thus, the composition can be used to deliver glucagon in an insulin responsive manner. The composition can be loaded into microneedles, for example, to prepare microneedle arrays for skin patches. Methods of delivering glucagon to a subject are also described.

Find Patent Forward Citations

Loading…