The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 19, 2023

Filed:

May. 06, 2020
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Henry M. Colecraft, Robbinsville, NJ (US);

Scott Kanner, New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/64 (2006.01); C12N 15/85 (2006.01); C12Q 1/6883 (2018.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6472 (2013.01); C12N 15/85 (2013.01); C12Q 1/6883 (2013.01); C12Y 304/22 (2013.01); A61K 38/00 (2013.01); C12Q 2600/156 (2013.01);
Abstract

The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.


Find Patent Forward Citations

Colecraft, Henry. (2023). Compositions and methods for using engineered deubiquitinases for probing ubiquitin-dependent cellular processes (U.S. Patent No. 11845967). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11845967

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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