The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2023
Filed:
Mar. 17, 2020
Applicant:
Regeneron Pharmaceuticals Inc., Tarrytown, NY (US);
Assignee:
Regeneron Pharmaceuticals Inc., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); G16B 20/00 (2019.01); G16B 30/00 (2019.01); C12Q 1/6874 (2018.01); G16B 25/00 (2019.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1079 (2013.01); C12Q 1/6874 (2013.01); G01N 33/5008 (2013.01); G16B 20/00 (2019.02); G16B 25/00 (2019.02); G16B 30/00 (2019.02);
Abstract
Methods and systems for CRISPR positive selection are described. CRISPR positive selection uses DNA sequencing to identify genes that their perturbation by CRISPR guide RNAs is correlated to the phenotype. In some aspects, disclosed are genome-wide CRISPR/Cas9 screening methods to identify genetic modifiers. Also disclosed are the apparatuses used for performing the methods.