The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2023
Filed:
Apr. 14, 2016
Applicant:
Tsinghua University, Beijing, CN;
Inventors:
Ting Zhu, Beijing, CN;
Yuval Ebenstein, Yavne, IL;
Chunbo Lou, Beijing, CN;
Wenjun Jiang, Beijing, CN;
Xuejin Zhao, Beijing, CN;
Tslil Gabrieli, Ramat-Yishai, IL;
Assignee:
Tsinghua University, Beijing, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
C12N 15/1003 (2013.01); C12N 15/101 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6869 (2013.01);
Abstract
A method of DNA fragmentation is provided. The method comprising incubating a semi-solid biological sample which comprises the DNA with an auxiliary domain-directed nuclease having a binding affinity and selectivity to pre-defined sites in the DNA so as to yield a DNA fragment-of-interest, to thereby fragment the DNA.