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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11845723 B1

PDFFull Text
Date of Patent:
Dec. 19, 2023

Filed:

Dec. 18, 2020

Diacylglycerol kinase modulating compounds

Applicants:

Gilead Sciences, Inc., Foster City, CA (US);

Carna Biosciences, Inc., Kobe, JP;

Inventors:

Masaaki Sawa, Kobe, JP;

Mai Arai, Kobe, JP;

Ryoko Nakai, Kobe, JP;

Hirokazu Matsumoto, Kobe, JP;

Catherine Pugh, Foster City, CA (US);

Eric Hu, Foster City, CA (US);

Juan Guerrero, Foster City, CA (US);

Jesse Jacobsen, Foster City, CA (US);

Jonathan William Medley, Foster City, CA (US);

Jie Xu, Foster City, CA (US);

Latesh Lad, Foster City, CA (US);

Leena Patel, Foster City, CA (US);

Michael Graupe, Foster City, CA (US);

Qingming Zhu, Foster City, CA (US);

Stephen Holmbo, Foster City, CA (US);

Tetsuya Kobayashi, Foster City, CA (US);

Will Watkins, Foster City, CA (US);

Yasamin Moazami, Foster City, CA (US);

Suet C. Yeung, Foster City, CA (US);

Julian A. Codelli, Foster City, CA (US);

Heath A. Weaver, Foster City, CA (US);

Assignee:

Gilead Sciences, Inc., Foster City, CA (US);

Attorney:
Primary Examiner:

Joseph R Kosack

Assistant Examiner:

Sagar Patel

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); A61K 31/704 (2006.01); A61K 31/7068 (2006.01); C07D 519/00 (2006.01); A61K 31/554 (2006.01); A61K 31/695 (2006.01); A61K 31/395 (2006.01); A61K 35/15 (2015.01); A61K 35/17 (2015.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07F 7/18 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/519 (2013.01); A61K 31/538 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61K 31/5545 (2017.08); A61K 31/695 (2013.01); A61K 31/704 (2013.01); A61K 31/7068 (2013.01); A61K 35/15 (2013.01); A61K 35/17 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07D 519/00 (2013.01); C07F 7/1804 (2013.01);
Abstract

The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

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