The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2023
Filed:
Dec. 02, 2019
Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang, CN;
Shanghai Aobo Pharmtech, Inc., Ltd., Shanghai, CN;
Chen Liu, Shanghai, CN;
Xing Li, Shanghai, CN;
Huaxiang Ye, Shanghai, CN;
Jicheng Zhang, Shanghai, CN;
Luning Huang, Shanghai, CN;
Anping Tao, Shanghai, CN;
Jianguo An, Shanghai, CN;
Hong Gu, Shanghai, CN;
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, Zhejiang, CN;
SHANGHAI AOBO PHARMTECH, INC., LTD., Shanghai, CN;
Abstract
The present application relates to a method for citalopram intermediate citalopram diol. The method comprises: first mixing two Grignard reagents required for a reaction; then mixing the mixed Grignard reagents with a raw material 5-cyanophthalide in a temperature-controllable micromixer to obtain a reaction solution; then subjecting the reaction solution to the reaction by means of a reactor to obtain a citalopram diol reaction solution; and then performing operations such as quenching, concentration, extraction, acidification, and crystallization to obtain a qualified product. The citalopram diol provided in the present invention has good selectivity, high yield, high safety, safety and reliability, and little sewage discharge, and is suitable for industrial production.