The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2023
Filed:
Nov. 22, 2021
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Yair Reisner, Houston, TX (US);
Noga Or-Geva, Rehovot, IL;
Eran Ophir, Rehovot, IL;
Yaki Eidelstein, Rehovot, IL;
Rotem Gidron Budovsky, Rehovot, IL;
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 35/17 (2015.01); C12N 5/078 (2010.01); C12N 5/0783 (2010.01); A61P 31/00 (2006.01); A61P 35/04 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 39/001 (2013.01); A61K 35/17 (2013.01); A61K 39/39566 (2013.01); A61P 31/00 (2018.01); A61P 35/04 (2018.01); C07K 16/2896 (2013.01); C12N 5/0636 (2013.01); C12N 5/0637 (2013.01); C12N 5/0648 (2013.01); A61K 2035/122 (2013.01); A61K 2039/5158 (2013.01); C12N 2501/2307 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/2321 (2013.01); Y02A 50/30 (2018.01);
Abstract
An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.