The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 19, 2023

Filed:

Mar. 23, 2023
Applicant:

Pacific Biosciences of California, Inc., Menlo Park, CA (US);

Inventors:

Benjamin Flusberg, Atlanta, GA (US);

Jonas Korlach, Camas, WA (US);

Andrey Kislyuk, San Ramon, CA (US);

Stephen Turner, Seattle, WA (US);

Jon Sorenson, Alameda, CA (US);

Kevin Travers, Menlo Park, CA (US);

Cheryl Heiner, La Honda, CA (US);

Austin B. Tomaney, Burlingame, CA (US);

Patrick Marks, San Francisco, CA (US);

Dale Webster, San Mateo, CA (US);

Jeremiah Hanes, Menlo Park, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G16B 30/00 (2019.01); A61F 2/30 (2006.01); C12Q 1/6858 (2018.01); C12Q 1/6869 (2018.01); A61F 2/32 (2006.01); A61F 2/40 (2006.01); A61F 2/46 (2006.01);
U.S. Cl.
CPC ...
A61F 2/30721 (2013.01); C12Q 1/6858 (2013.01); C12Q 1/6869 (2013.01); G16B 30/00 (2019.02); A61F 2/30767 (2013.01); A61F 2/30965 (2013.01); A61F 2/32 (2013.01); A61F 2/40 (2013.01); A61F 2002/30004 (2013.01); A61F 2002/30062 (2013.01); A61F 2002/30235 (2013.01); A61F 2002/30242 (2013.01); A61F 2002/30245 (2013.01); A61F 2002/30324 (2013.01); A61F 2002/30593 (2013.01); A61F 2002/30757 (2013.01); A61F 2002/30971 (2013.01); A61F 2002/4635 (2013.01); A61F 2210/0004 (2013.01); A61F 2230/0069 (2013.01); A61F 2230/0071 (2013.01); A61F 2250/0014 (2013.01); A61F 2250/0036 (2013.01);
Abstract

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.


Find Patent Forward Citations

Loading…