The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2023
Filed:
May. 30, 2017
Applicant:
Institut DE Cardiologie DE Montreal, Montreal, CA;
Inventors:
David Rhainds, Montréal, CA;
Éric Rhéaume, Montréal, CA;
David Busseuil, Montréal, CA;
Jean-Claude Tardif, Laval, CA;
Assignee:
INSTITUT DE CARDIOLOGIE DE MONTREAL, Montreal, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12M 3/06 (2006.01); C12M 1/04 (2006.01); C12M 1/00 (2006.01); C12N 5/0786 (2010.01); C12N 5/074 (2010.01); C12Q 1/60 (2006.01); C12M 1/34 (2006.01); G01N 33/92 (2006.01); C12M 3/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/067 (2013.01); C12M 1/34 (2013.01); C12M 3/00 (2013.01); C12M 23/16 (2013.01); C12M 23/24 (2013.01); C12M 23/34 (2013.01); C12N 5/0645 (2013.01); C12N 5/0696 (2013.01); C12Q 1/60 (2013.01); G01N 33/92 (2013.01); C12N 2502/1157 (2013.01); C12N 2502/14 (2013.01); C12N 2503/02 (2013.01);
Abstract
The present invention provides a co-culture system and method for assessing cellular cholesterol (Choi) efflux and uptake in vitro. The co-culture system mimics in vivo Choi efflux and uptake in the context of mammalian physiology. The methods and systems provided can be used in some embodiments to evaluate the effect of a pharmacological agent on cellular Choi efflux and uptake or for diagnostic purposes.