The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2023
Filed:
Nov. 12, 2021
Applicant:
University of Miami, Miami, FL (US);
Inventors:
Robert W. Keane, Miami, FL (US);
W. Dalton Dietrich, Miami, FL (US);
Juan Pablo De Rivero Vaccari, Miami, FL (US);
Helen M. Bramlett, Miami, FL (US);
Assignee:
UNIVERSITY OF MIAMI, Miami, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 11/00 (2006.01); C07K 16/18 (2006.01); C07K 16/24 (2006.01); A61P 25/28 (2006.01); A61P 25/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61P 29/00 (2006.01); A61K 31/727 (2006.01); A61P 25/14 (2006.01); A61P 37/06 (2006.01);
U.S. Cl.
CPC ...
C07K 16/24 (2013.01); A61K 31/727 (2013.01); A61K 39/3955 (2013.01); A61K 39/39541 (2013.01); A61P 11/00 (2018.01); A61P 25/00 (2018.01); A61P 25/14 (2018.01); A61P 25/28 (2018.01); A61P 29/00 (2018.01); A61P 37/06 (2018.01); C07K 16/18 (2013.01); A61K 2039/505 (2013.01); A61K 2039/55 (2013.01); A61K 2039/55522 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01);
Abstract
The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for treating viral-associated lung inflammation, for example lung inflammation associated with viral infections such as SARS-CoV-2.